tolerance – the diminishing effect of a drug resulting from repeated administration at a given dose.substance use disorder – a condition in which the use of substances leads to clinically and functionally significant impairment or distress.sensitization – an amplified response to a stimulus resulting from repeated exposure to it. ![]() rewarding stimuli – stimuli that the brain interprets as intrinsically positive and desirable or as something to approach.reinforcing stimuli – stimuli that increase the probability of repeating behaviors paired with them. ![]() psychological dependence – dependence that involves emotional–motivational withdrawal symptoms (e.g., dysphoria and anhedonia). ![]()
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